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A preclinical study done in a mouse model of ALS (wobbler mice) showed that treatment with an ultra-high dose of methylcobalamin inhibits disease progression

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Studies have investigated its effects in models of nerve damage and neuroinflammation, with findings suggesting neuroprotective activity and potential influence on nerve growth factor (NGF) expression

Data on the safety and efficacy of such therapies over decades are lacking, creating uncertainty about their role in chronic use, Roberts says

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